Dr. David S. Alberts, director of the Arizona Cancer Center, is principal investigator for the assignment of Cancer Prevention National Institutes of Health, which provided the funding of the study.Objective INPP5A could provide doctors with better ways to prevent and treat skin cancer squamous cell carcinoma, or SCC, a tumor of the skin that often spreads to other parts of the body, according to a scientific article published in the journal Cancer Prevention.
More than 1 million non-melanoma skin cancer are diagnosed each year in the U.S., making it the most common type of cancer and the fifth most expensive in the population, those Americans aged 65 years. The vast majority of non-melanoma skin cancers are basal cell carcinoma and SCC
The loss of INPP5A can be detected in primary tumors and also in the CSC actinic keratosis, or AK, already in the development of SCC, said Aleksandar Sekulic, MD, Ph.D. Above all, a further reduction INPP5A was recognized as a subgroup of SCC tumors passed from primary to metastatic stage.
The study used advanced technology to analyze genomic TGen 40 tissue samples of skin from normal skin are highly invasive SCC. In particular, the researchers used a technique called high-resolution array-based comparative genomics to identify hybirdization genetic deletions in a portion of DNA containing the gene normally INPP5A.
Genetic mutations contribute to the development and progression of cancer by stimulating the cells to multiply too fast, or interfere with the normal processes that allow them to die, according to the newspaper, the loss of inositol polyphosphate 5-phosphatase is an early event in the development of Squamous cell skin cancer.
At present, our ability to assess who is at risk of SCC and our ability to treat the disease, especially in its more aggressive forms, is clearly insufficient, said Dr. Jeffrey Trent, TGen President and head of research and one of the authors of the study. Without doubt, further investigations are warranted in INPP5A.
Dr Oddy said that although this study suggests that diet may be involved in ADHD, further research is needed to determine the nature of the relationship.
The deletions observed in INPP5A represents a highly selected, non-random genetic event in the CSC, to give confidence to researchers that it is a biomarker with a great potential for the clinical trial and patient benefit, said Dr.
Albert, a Another author of the Regents and professor of Medicine, Pharmacology, Nutrition and Public Health Sciences at the University of Arizona College of Medicine.
Source: http://www.optimo-si.com/?p=638
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